Junctate is a key element in calcium entry induced by activation of InsP
نویسندگان
چکیده
1 Department of Anesthesiology, 2 Department of Research, and 3 Department of Transplant Immunology, University of Basel Kantosspital, Basel, 4031 Switzerland 4 Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 5 Dipartimento di Medicina Sperimentale e Diagnostica, Università di Ferrara, 44100 Ferrara, Italy 6 Centre for Molecular Neurobiology and 7 Department of Neuroscience, Ohio State University, Columbus, OH 43210 8 RIKEN BSI Saitama, ICORP, JST, Tokyo and 9 Institute of Medical Science, University of Tokyo, Tokyo, 108-8639 Japan 10 Laboratoire Canaux Calciques, Fonctions et Pathologies, INSERM U607, CEA-Grenoble, France
منابع مشابه
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion
In many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs). Stimulated cells activate store- or receptor-operated calcium channels localized in the plasma membrane, allowing entry of extracellular calcium into the cytoplasm, and thus replenishment of intr...
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The acrosome reaction, the first step of the fertilization, is induced by calcium influx through Canonical Transient Receptor Potential channels (TRPC). The molecular nature of TRPC involved is still a debated question. In mouse, TRPC2 plays the most important role and is responsible for the calcium plateau. However, TRPC1 and TRPC5 are also localized in the acrosomal crescent of the sperm head...
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The precise localization and role of inositol 1,4,5-trisphosphate (InsP(3)) receptors (InsP(3)Rs) in cardiac muscle cells are largely unknown. It is believed that waves and oscillations in cytosolic free calcium triggered by activation of InsP(3)Rs underlie modifications of cellular responses that lead to changes in gene expression in other cells. However, how changes in cytosolic calcium alter...
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The cytosolic Ca(2+) concentration ([Ca(2+)](c)) controls diverse cellular events via various Ca(2+) signaling patterns; the latter are influenced by the method of cell activation. Here, in single-voltage clamped smooth muscle cells, sarcolemma depolarization generated uniform increases in [Ca(2+)](c) throughout the cell entirely by Ca(2+) influx. On the other hand, the Ca(2+) signal produced b...
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تاریخ انتشار 2004